Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31641754 | 0.90 | MAPK1 (0.54) | POLBMAPK1GAACCR1ATM | |
| SCHEMBL6912119 | 0.87 | CCR1 (0.62) | CCR1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9891789 | 0.82 | MAPK1 (0.62) | POLBMAPK1GAAALDH1A1MEN1 | |
| SCHEMBL11833579 | 0.80 | MAPK1 (0.59) | POLBMAPK1GAACCR1ALDH1A1 | |
| SCHEMBL6911412 | 0.79 | GAA (0.44) | POLBGAACCR1ALDH1A1LMNA | |
| SCHEMBL13645833 | 0.78 | CCR1 (0.66) | POLBMAPK1GAACCR1ATM | |
| SCHEMBL16357643 | 0.78 | MAPK1 (0.57) | POLBMAPK1GAACCR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7632441 | 0.78 | MAPK1 (0.57) | POLBMAPK1GAACCR1ALDH1A1 | |
| SCHEMBL11049712 | 0.78 | GAA (0.68) | POLBMAPK1GAAATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL6913635 | 0.78 | MAPK1 (0.57) | POLBMAPK1GAACCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825200-B1 | TREATING, PROLONGING, OR EXTENDING THE ONSET OF ORGAN REJECTION IN A HUMAN DURING OR AFTER ORGAN TRANSPLANTATION IN A HUMAN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1226159-A1 | SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032690-A1 | SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-10 | — | — | WO | disclosed |