Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 15/20 | 1.00 |
| ▸ | BRAF | P15056 | 10/20 | 1.00 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912939 | 1.00 | TNNI3K (1.00) | TNNI3KBRAFEGFRLRRK2RET | |
| Hydrochloric Acid SCHEMBL12003571 | 0.99 | TNNI3K (0.98) | TNNI3KBRAFEGFRLRRK2RET | |
| SCHEMBL6910954 | 0.96 | TNNI3K (0.93) | TNNI3KBRAFEGFR | |
| SCHEMBL6910868 | 0.95 | TNNI3K (1.00) | TNNI3KBRAFEGFRLRRK2RET | |
| Trifluoroacetic Acid SCHEMBL12004269 | 0.95 | TNNI3K (0.91) | TNNI3KBRAFEGFRLRRK2RET | |
| Hydrochloric Acid SCHEMBL12003636 | 0.95 | TNNI3K (0.98) | TNNI3KBRAFEGFRLRRK2RET | |
| SCHEMBL1807210 | 0.91 | TNNI3K (0.88) | TNNI3KBRAFEGFR | |
| SCHEMBL6911975 | 0.90 | TNNI3K (0.85) | TNNI3KBRAFEGFRLRRK2RET | |
| SCHEMBL6912666 | 0.90 | TNNI3K (1.00) | TNNI3KBRAFEGFRLRRK2RET | |
| SCHEMBL1807757 | 0.90 | TNNI3K (1.00) | TNNI3KBRAFEGFRLRRK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | claimed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | claimed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | claimed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | NQO2, PRMT7, QDPR | TNNI3K 532/4885BRAF 1665/4885EGFR 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.