Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.66 |
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.66 |
| ▸ | PDE5A | O76074 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.66 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CA3 | P07451 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29502699 | 1.00 | PTGS2 (0.66) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8637585 | 0.91 | PDPK1 (0.69) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8640768 | 0.90 | PTGS2 (0.67) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8693374 | 0.90 | PDPK1 (0.69) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8643577 | 0.89 | PTGS2 (0.65) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL5694290 | 0.89 | PTGS2 (0.65) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8641581 | 0.89 | PTGS2 (0.65) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8641602 | 0.89 | PTGS2 (0.53) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8638534 | 0.89 | PTGS2 (0.69) | PTGS2PDPK1PTGS1CYP2C9PTGES | |
| SCHEMBL8639798 | 0.88 | PTGS2 (0.66) | PTGS2PDPK1PTGS1CYP2C9RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001527542-A | — | — | 2001-12-25 | — | — | JP | claimed |
| EP-0979077-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. Searle & Co. (US) | 2000-02-16 | — | — | EP | claimed |
| US-5910597-A | Process for preparing 3-haloalkyl-1H-pyrazoles | G.D. SEARLE & CO. (US) | 1999-06-08 | — | — | US | claimed |
| US-5892053-A | Process for preparing 3-haloalkyl-1H-pyrazoles | G. D. SEARLE & CO. (US) | 1999-04-06 | — | — | US | claimed |
| WO-1998047509-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1998-10-29 | — | — | WO | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| WO-2004014378-A1 | 3-ISOQUINOLINONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2003024400-A2 | PROCESS FOR THE PREPARATION OF 1,5-DIARYLPYRAZOLES | ONCONOVA THERAPEUTICS, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
| US-5932598-A | NOVEL SUBSTITUTED SULFONAMIDE COMPOUNDS USEFUL AS PRODRUGS; ADMINISTERING TO TREAT INFLAMMATION-ASSOCIATED PAIN DUE TO CANCER, DENTAL PAIN; CYCLOOXYGENASE-2 INHIBITORS | G. D. SEARLE & CO. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5910597-A | Process for preparing 3-haloalkyl-1H-pyrazoles | G.D. SEARLE & CO. (US) | 1999-06-08 | — | — | US | disclosed |
| US-5892053-A | Process for preparing 3-haloalkyl-1H-pyrazoles | G. D. SEARLE & CO. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |
| EP-0731795-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |