SCHEMBL6912936

SCHEMBL6912936

CC(=O)OCCCCC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC(=O)[C@@]1(C)C[C@@H]2F

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 12/20 0.37
AR P10275 5/20 0.36
ESR1 P03372 1/20 0.35
PGR P06401 1/20 0.35
NR3C1 P04150 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6854222 0.87 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL4001776 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL3999426 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL6852290 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL13809850 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL6853911 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL13804521 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL6849201 0.86 CYP19A1 (0.40) CYP19A1ARESR1
SCHEMBL7030182 0.85 CYP19A1 (0.49) CYP19A1ARPGR
SCHEMBL9626851 0.85 CYP19A1 (0.49) CYP19A1ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5986115-A STEROIDS WITH FLUORO GROUPS AND ETHER OR ESTER GROUPS SCHERING AG (DE) 1999-11-16 US claimed
US-6677324-B1 MIXTURE INCLUDES 7A-(E-AMINOALKYL)-ESTRATRIENE; HORMONE REPLACEMENT THERAPY; MENOPAUSE SCHERING AKTIENGESELLSCHAFT (DE) 2004-01-13 US disclosed
EP-0920441-B1 7ALPHA-(EPSILON-AMINOALKYL)-ESTRATRIENES, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 7ALPHA-(EPSILON-AMINOALKYL)-ESTRATRIENES AND THEIR USE FOR PREPARING MEDICAMENT SCHERING AG (DE) 2003-01-29 EP disclosed
US-6271403-B1 PURE ANTIESTROGENS, OR ESTROGENIC ANTIESTROGENS WITH ESTROGENIC PARTIAL ACTION. SCHERING AKTIENGESELLSCHAFT (DE) 2001-08-07 US disclosed
US-5986115-A STEROIDS WITH FLUORO GROUPS AND ETHER OR ESTER GROUPS SCHERING AG (DE) 1999-11-16 US disclosed
US-5866560-A ESTROGEN INHIBITORS; TUMOR THERAPY; HORMONE REPLACEMENT THERAPY SCHERING AG (DE) 1999-02-02 US disclosed