Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 6/20 | 0.44 |
| ▸ | HTR1D | P28221 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820063 | 0.86 | HTR1B (0.53) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL7062951 | 0.85 | HTR1B (0.52) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL7063741 | 0.85 | HTR1B (0.52) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL7063234 | 0.85 | HTR1B (0.52) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL6569460 | 0.79 | GAA (0.49) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL6816431 | 0.74 | HTR1B (0.58) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL6816422 | 0.74 | HTR1B (0.58) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL6816404 | 0.74 | HTR1B (0.58) | HTR1BKCNH2MAPTRAB9ANPC1 | |
| SCHEMBL6819644 | 0.72 | MAPT (0.55) | MAPTRAB9ANPC1KMT2APOLB | |
| SCHEMBL6824086 | 0.71 | HTR1B (0.56) | HTR1BKCNH2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014986-B1 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT 1 BETA ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-07-14 | — | — | EP | claimed |
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | claimed |
| EP-1014985-B1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A H5-HT 1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2003-05-21 | — | — | EP | claimed |