Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1504396 | 0.99 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1470446 | 0.90 | CTSD (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1470444 | 0.90 | CTSD (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1470449 | 0.90 | CTSD (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| Hydrochloric Acid SCHEMBL1846579 | 0.89 | CTSD (0.55) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1570232 | 0.79 | CTSD (0.52) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1570511 | 0.78 | CTSD (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1570513 | 0.78 | CTSD (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1570059 | 0.78 | CTSD (0.45) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD | |
| SCHEMBL1467754 | 0.77 | CTSD (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470537-A2 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-07-04 | — | — | EP | disclosed |
| EP-2459562-A1 | PYRROLO [1, 2-B]PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-2421867-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | Auspex Pharmaceuticals, Llc (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2011031554-A2 | HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011014817-A1 | PYRROLO [1, 2-B] PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |
| WO-2010123919-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, LLC (US) | 2010-10-28 | — | — | WO | disclosed |