SCHEMBL6915546

SCHEMBL6915546

CC(O)(Cc1ccccc1)C(=O)S

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.47
HIF1A Q16665 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
SLC6A2 P23975 1/20 0.47
TAAR1 Q96RJ0 1/20 0.47
FDPS P14324 1/20 0.46
CYP2C19 P33261 3/20 0.45
CYP2C9 P11712 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP3A4 P08684 3/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 2/20 0.44
CYP2D6 P10635 2/20 0.44
MMP8 P22894 5/20 0.42
RECQL P46063 1/20 0.42
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
MAPK1 P28482 1/20 0.41
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL180161 0.83 SMN1; SMN2 (0.55) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL1275761 0.83 SMN1; SMN2 (0.55) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL3361395 0.83 SMN1; SMN2 (0.55) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL4359977 0.83 SMN1; SMN2 (0.50) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL2927672 0.82 SMN1; SMN2 (0.48) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL9784950 0.82 TRPA1 (0.48) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL6912517 0.81 AR (0.47) HIF1ASMN1; SMN2FDPSCYP2C19ALDH1A1
SCHEMBL6914641 0.81 AR (0.47) HIF1ASMN1; SMN2FDPSCYP2C19ALDH1A1
SCHEMBL23572607 0.80 SMN1; SMN2 (0.47) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1
SCHEMBL1059557 0.80 SLC6A2 (0.52) TRPA1HIF1ASMN1; SMN2SLC6A2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6818423-B2 LOW-MOLECULAR-WEIGHT C4-C6-KETONES DERIVATIZED WITH REMOVABLE GROUP ARE REACTED WITH CYANIDE GROUP DONOR IN PRESENCE OF HYDROXYNITRILE LYASE OR BY RACEMIC REACTION, ACIDIC HYDROLYSIS, OPTIONALLY RESOLUTION, AND CLEAVAGE OF THE GROUP DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AU) 2004-11-16 US disclosed
US-20030092142-A1 Process for the preparation of chiral alpha-hydroxycarboxylic acids DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) 2003-05-15 US disclosed
EP-0100172-B1 AMIDE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-08-12 EP disclosed
US-4636505-A ANTIANDROGENS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-01-13 US disclosed
EP-0100172-A1 Amide derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-02-08 EP disclosed