Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437453 | 0.86 | HDAC3 (0.49) | NPC1L3MBTL1USP2ALDH1A1MAPT | |
| SCHEMBL7567842 | 0.85 | NPC1 (0.43) | NPC1L3MBTL1ATMGAAADRA1A | |
| SCHEMBL30777649 | 0.85 | ADRB1 (0.49) | MAPTADRA1AADRA1B | |
| SCHEMBL8219392 | 0.85 | ADRB1 (0.49) | MAPTADRA1AADRA1B | |
| SCHEMBL23708768 | 0.82 | NPC1 (0.60) | NPC1L3MBTL1ATMHTTNPSR1 | |
| SCHEMBL5481818 | 0.81 | NOTUM (0.49) | NPC1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11985491 | 0.79 | NPC1 (0.60) | NPC1L3MBTL1ATMPTPN1HTT | |
| SCHEMBL6139909 | 0.78 | MYC (0.42) | NPC1L3MBTL1ATMKMT2AMEN1 | |
| SCHEMBL28965465 | 0.78 | TSHR (0.61) | NPC1L3MBTL1ATMALDH1A1TSHR | |
| SCHEMBL30111657 | 0.77 | TSHR (0.50) | NPC1L3MBTL1HTTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2004-09-08 | — | — | EP | disclosed |