Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917345 | 0.90 | PDE10A (0.61) | PDE10ATP53RXFP1 | |
| SCHEMBL12314872 | 0.90 | PDE10A (0.61) | PDE10ANR4A2MAPTKDM4EALDH1A1 | |
| SCHEMBL12316438 | 0.90 | PDE10A (0.74) | PDE10A | |
| SCHEMBL2385774 | 0.90 | PDE10A (0.69) | PDE10ATP53RXFP1 | |
| SCHEMBL2372991 | 0.87 | PDE10A (0.59) | PDE10A | |
| SCHEMBL6915413 | 0.84 | PDE10A (0.62) | PDE10ATP53MAPTKDM4EALDH1A1 | |
| SCHEMBL6916959 | 0.84 | PDE10A (0.69) | PDE10ATP53POLBMAPT | |
| SCHEMBL14672680 | 0.82 | PDE10A (0.64) | PDE10ATP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL14672699 | 0.82 | PDE10A (0.64) | PDE10AMAPTALDH1A1 | |
| SCHEMBL2397443 | 0.82 | PDE10A (0.77) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |