Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.59 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 8/20 | 0.44 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693380 | 0.93 | PTK2 (0.59) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL691087 | 0.93 | PTK2 (0.60) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL690218 | 0.92 | PTK2 (0.58) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL691296 | 0.91 | PTK2 (0.56) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL692967 | 0.90 | PTK2 (0.73) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL691570 | 0.90 | PTK2 (0.56) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL691330 | 0.88 | PTK2 (0.58) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL1292918 | 0.88 | PTK2 (0.63) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL691756 | 0.84 | PTK2 (0.59) | PTK2MAPK3MAPK1MAPK10MAPK9 | |
| SCHEMBL690533 | 0.84 | MAPK3 (0.55) | PTK2MAPK3MAPK1MAPK10MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | claimed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | claimed |