Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691652 | 0.92 | PTK2 (0.57) | PTK2FTOGFERMAPTMEN1 | |
| SCHEMBL691659 | 0.91 | PTK2 (0.59) | PTK2MAPK3MAPK1MAPK8JAK2 | |
| SCHEMBL690218 | 0.90 | PTK2 (0.58) | PTK2MT-CO2HPGDPTGS2MAPK3 | |
| SCHEMBL691084 | 0.90 | PTK2 (0.47) | PTK2MAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL689985 | 0.90 | PTK2 (0.45) | PTK2MEN1KMT2AUSP2LMNA | |
| SCHEMBL692967 | 0.88 | PTK2 (0.73) | PTK2MEN1KMT2APTGS2MAPK3 | |
| SCHEMBL691573 | 0.88 | MAPK1 (0.50) | PTK2FTOMEN1KMT2ALMNA | |
| SCHEMBL691390 | 0.88 | PTK2 (0.46) | PTK2FTOLMNAMAPK3MAPK1 | |
| SCHEMBL697233 | 0.87 | PTK2 (0.60) | PTK2FTOGFERMAPTMEN1 | |
| SCHEMBL691211 | 0.87 | PTK2 (0.44) | PTK2FTOMEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |