Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28241668 | 0.85 | SKP2 (0.37) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL28241665 | 0.78 | PTGS2 (0.38) | HTTMAPTCYP3A4TYRTSHR | |
| SCHEMBL28247083 | 0.77 | TYR (0.43) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL1238349 | 0.75 | TYR (0.41) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL2697153 | 0.75 | HTT (0.37) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL30945773 | 0.75 | HPGD (0.48) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL983815 | 0.75 | HPGD (0.48) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL9359662 | 0.75 | SKP2 (0.53) | SKP2HTTNPC1HPGDMAPK1 | |
| SCHEMBL29487433 | 0.74 | TYR (0.44) | SKP2HTTCYP3A4TYRKDM4E | |
| SCHEMBL5933485 | 0.74 | TYR (0.44) | SKP2HTTCYP3A4TYRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003754-B1 | METHOD OF MANUFACTURING PHOSPHINE COMPOUND | LUCITE INT UK LTD (GB) | 2004-02-11 | — | — | EP | disclosed |
| EP-1064288-B1 | PROCESS FOR THE PREPARATION OF BISPHOSPHINES | LUCITE INT UK LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-6376715-B1 | FROM AN ORGANOMETALLIC COMPOUND | INEOS ACRYLICS U.K. LIMITED (GB) | 2002-04-23 | — | — | US | disclosed |
| US-6335471-B1 | REACTING DIHALOALKYL ARYL COMPOUND WITH METAL TO FORM GRIGNARD REAGENT, REACTING WITH DISUBSTITUTED PHOSPHINE HALIDE TO FORM DIPHOSPHINE COMPOUND USEFUL AS LIGAND FOR CARBONYLATION CATALYSTS | INEOS ACRYLICS UK LIMITED (GB) | 2002-01-01 | — | — | US | disclosed |