Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 12/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918443 | 0.87 | KMO (0.65) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2280592 | 0.83 | KMO (0.60) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2278992 | 0.80 | KMO (0.56) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2280622 | 0.80 | KMO (0.56) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2291147 | 0.75 | KMO (1.00) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2281232 | 0.75 | KMO (0.51) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL2286344 | 0.75 | KMO (0.51) | KMONPC1RAB9ATP53MAPT | |
| SCHEMBL14742330 | 0.74 | KMO (1.00) | KMONPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL2227125 | 0.70 | KMO (0.68) | KMO | |
| SCHEMBL2229377 | 0.70 | KMO (0.63) | KMODYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091153-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-07-28 | — | — | WO | disclosed |