SCHEMBL691772

SCHEMBL691772

C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(Cl)c1)c1ccc(C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 20/20 1.00
PTGER2 P43116 6/20 0.85
PTGDR Q13258 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26914665 1.00 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL29453297 1.00 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL27666414 0.93 PTGER4 (0.86) PTGER4PTGER2PTGDR
SCHEMBL30114913 0.93 PTGER4 (0.86) PTGER4PTGER2PTGDR
SCHEMBL4452650 0.93 PTGER4 (0.86) PTGER4PTGER2
SCHEMBL693132 0.93 PTGER4 (0.86) PTGER4PTGER2PTGDR
SCHEMBL26914663 0.92 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL692097 0.92 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL4443161 0.91 PTGER4 (0.83) PTGER4PTGER2
SCHEMBL30114774 0.88 PTGER4 (0.83) PTGER4PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2017-09-07 US claimed
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2016-11-03 US claimed
EP-2976105-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE AskAt Inc. (JP) 2016-01-27 EP claimed
WO-2014148053-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2014-09-25 WO claimed
EP-1663979-B1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS RAQUALIA PHARMA INC (JP) 2013-10-09 EP claimed
CN-1867551-B Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists RAQUALIA PHARMA INC 2013-09-11 CN claimed
EP-2538978-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RaQualia Pharma Inc (JP) 2013-01-02 EP claimed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US claimed
CN-102770159-A Use of EP-4 receptor antagonists for the treatment of IL-23 mediated diseases RAQUALIA PHARMA INC 2012-11-07 CN claimed
CN-102421429-A Selective EP4 receptor antagonist for cancer therapy RAQUALIA PHARMA INC 2012-04-18 CN claimed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP claimed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO claimed
WO-2005102389-A9 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PROD INC (US) 2009-04-30 WO claimed
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PFIZER, INC. 2009-02-05 US claimed
US-7238714-B2 Aryl or heteroaryl amide compounds PFIZER JAPAN, INC. (JP) 2007-07-03 US claimed
CN-1946391-A Combinations comprising alpha-2-delta ligands PFIZER PROD INC (US) 2007-04-11 CN claimed
EP-1740211-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS Pfizer Products Incorporated (US) 2007-01-10 EP claimed
CN-1867551-A Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists PFIZER (US) 2006-11-22 CN claimed
WO-2005102389-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-03 WO claimed
US-20050065188-A1 Aryl or heteroaryl amide compounds ASKAT INC. (JP) 2005-03-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES PTGER4, PTGER3, IL23R PTGER4 1/4885PTGER2 6/4885PTGDR 15/4885
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGDR 11/4885
US-20050065188-A1 Aryl or heteroaryl amide compounds HRH2, PTGER1, LTB4R2 PTGER4 13/4885PTGER2 11/4885PTGDR 16/4885
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PTGER4, PTGER2, OPRL1 PTGER4 1/4885PTGER2 2/4885PTGDR 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.