SCHEMBL692097

SCHEMBL692097

C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 20/20 1.00
PTGER2 P43116 5/20 1.00
PTGDR Q13258 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26914663 1.00 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL26914665 0.92 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL691772 0.92 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL29453297 0.92 PTGER4 (1.00) PTGER4PTGER2PTGDR
SCHEMBL4444900 0.91 PTGER4 (0.84) PTGER4PTGER2
SCHEMBL30114837 0.91 PTGER4 (0.85) PTGER4PTGER2PTGDR
SCHEMBL691367 0.91 PTGER4 (0.85) PTGER4PTGER2PTGDR
SCHEMBL30114822 0.89 PTGER4 (0.81) PTGER4PTGER2PTGDR
SCHEMBL27666415 0.89 PTGER4 (0.81) PTGER4PTGER2PTGDR
SCHEMBL2353288 0.89 PTGER4 (0.81) PTGER4PTGER2PTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2017-09-07 US claimed
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2016-11-03 US claimed
EP-2976105-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE AskAt Inc. (JP) 2016-01-27 EP claimed
WO-2014148053-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2014-09-25 WO claimed
EP-1663979-B1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS RAQUALIA PHARMA INC (JP) 2013-10-09 EP claimed
CN-1867551-B Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists RAQUALIA PHARMA INC 2013-09-11 CN claimed
EP-2538978-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RaQualia Pharma Inc (JP) 2013-01-02 EP claimed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US claimed
CN-102770159-A Use of EP-4 receptor antagonists for the treatment of IL-23 mediated diseases RAQUALIA PHARMA INC 2012-11-07 CN claimed
CN-102421429-A Selective EP4 receptor antagonist for cancer therapy RAQUALIA PHARMA INC 2012-04-18 CN claimed
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RAQUALIA PHARMA INC. (JP) 2012-04-12 US claimed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP claimed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO claimed
WO-2005102389-A9 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PROD INC (US) 2009-04-30 WO claimed
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PFIZER, INC. 2009-02-05 US claimed
US-7238714-B2 Aryl or heteroaryl amide compounds PFIZER JAPAN, INC. (JP) 2007-07-03 US claimed
CN-1946391-A Combinations comprising alpha-2-delta ligands PFIZER PROD INC (US) 2007-04-11 CN claimed
CN-1867551-A Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists PFIZER (US) 2006-11-22 CN claimed
US-20050065188-A1 Aryl or heteroaryl amide compounds ASKAT INC. (JP) 2005-03-24 US claimed
US-20240066040-A1 EP4 INHIBITORS AND USE THEREOF ARRYS THERAPEUTICS INC (US) 2024-02-29 US disclosed
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2023-12-12 US disclosed
EP-2976105-B1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC (JP) 2023-01-04 EP disclosed
US-20220073510-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2022-03-10 US disclosed
US-20210290641-A1 EP4 INHIBITORS AND USE THEREOF ASKAT INC. (JP) 2021-09-23 US disclosed
US-10973834-B2 EP4 inhibitors and use thereof Arrys Therapeutics, Inc. (US) 2021-04-13 US disclosed
US-10947235-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2021-03-16 US disclosed
US-10786490-B2 Use of EP4 receptor antagonists in the treatment of cartilage disease ASKAT INC. (JP) 2020-09-29 US disclosed
US-20200188367-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2020-06-18 US disclosed
US-10611761-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2020-04-07 US disclosed
US-20190314390-A1 EP4 INHIBITORS AND USE THEREOF ASKAT INC. (JP) 2019-10-17 US disclosed
US-10391086-B2 Use of EP4 receptor antagonists in the treatment of cartilage disease ASKAT INC. (JP) 2019-08-27 US disclosed
EP-3431085-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER AskAt Inc. (JP) 2019-01-23 EP disclosed
US-20180193324-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2018-07-12 US disclosed
US-20170360764-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2017-12-21 US disclosed
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2017-09-07 US disclosed
US-9688674-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2017-06-27 US disclosed
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2016-11-03 US disclosed
US-9457084-B2 Use of EP4 receptor antagonists in the treatment of IL-23 mediated diseases RAQUALIA PHARMA INC. (JP) 2016-10-04 US disclosed
CN-102421429-B Selective EP4 receptor antagonist for cancer therapy 拉夸里亚创药株式会社 2016-08-17 CN disclosed
EP-2976105-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE AskAt Inc. (JP) 2016-01-27 EP disclosed
EP-2965756-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2016-01-13 EP disclosed
US-20150111920-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2015-04-23 US disclosed
US-8921391-B2 Selective EP4 receptor antagonistic substance for treatment of cancer RAQUALIA PHARMA INC. (JP) 2014-12-30 US disclosed
WO-2014148053-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2014-09-25 WO disclosed
EP-1663979-B1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS RAQUALIA PHARMA INC (JP) 2013-10-09 EP disclosed
CN-1867551-B Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists RAQUALIA PHARMA INC 2013-09-11 CN disclosed
EP-2538978-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RaQualia Pharma Inc (JP) 2013-01-02 EP disclosed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US disclosed
CN-102770159-A Use of EP-4 receptor antagonists for the treatment of IL-23 mediated diseases RAQUALIA PHARMA INC 2012-11-07 CN disclosed
CN-102421429-A Selective EP4 receptor antagonist for cancer therapy RAQUALIA PHARMA INC 2012-04-18 CN disclosed
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RAQUALIA PHARMA INC. (JP) 2012-04-12 US disclosed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP disclosed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO disclosed
WO-2005102389-A9 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PROD INC (US) 2009-04-30 WO disclosed
WO-2005102389-A9 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PROD INC (US) 2009-04-30 WO disclosed
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PFIZER, INC. 2009-02-05 US disclosed
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PFIZER, INC. 2009-02-05 US disclosed
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PFIZER, INC. 2009-02-05 US disclosed
US-7238714-B2 Aryl or heteroaryl amide compounds PFIZER JAPAN, INC. (JP) 2007-07-03 US disclosed
US-7238714-B2 Aryl or heteroaryl amide compounds PFIZER JAPAN, INC. (JP) 2007-07-03 US disclosed
US-7238714-B2 Aryl or heteroaryl amide compounds PFIZER JAPAN, INC. (JP) 2007-07-03 US disclosed
CN-1946391-A Combinations comprising alpha-2-delta ligands PFIZER PROD INC (US) 2007-04-11 CN disclosed
EP-1740211-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS Pfizer Products Incorporated (US) 2007-01-10 EP disclosed
CN-1867551-A Phenyl or pyridyl amide compounds as prostaglandin E2 antagonists PFIZER (US) 2006-11-22 CN disclosed
EP-1663979-A1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS PFIZER INC. (US) 2006-06-07 EP disclosed
WO-2005102389-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-03 WO disclosed
WO-2005102389-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-03 WO disclosed
US-20050065188-A1 Aryl or heteroaryl amide compounds ASKAT INC. (JP) 2005-03-24 US disclosed
WO-2005021508-A1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS PFIZER INC. (US) 2005-03-10 WO disclosed
WO-2005021508-A1 PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS PFIZER INC. (US) 2005-03-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (20 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210290641-A1 EP4 INHIBITORS AND USE THEREOF PTGER4, EPB41, PTGER1 PTGER4 1/4885PTGER2 5/4885PTGDR 68/4885
US-10391086-B2 Use of EP4 receptor antagonists in the treatment of cartilage disease PTGER4, PTGER1, EPB41 PTGER4 1/4885PTGER2 7/4885PTGDR 20/4885
US-20190314390-A1 EP4 INHIBITORS AND USE THEREOF PTGER4, EPB41, PTGER1 PTGER4 1/4885PTGER2 5/4885PTGDR 68/4885
US-10786490-B2 Use of EP4 receptor antagonists in the treatment of cartilage disease PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGDR 11/4885
US-10947235-B2 Selective EP4 receptor antagonistic substance for treatment of cancer PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES PTGER4, PTGER3, IL23R PTGER4 1/4885PTGER2 6/4885PTGDR 15/4885
US-20170360764-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGDR 11/4885
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20220073510-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20180193324-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, EPB41 PTGER4 1/4885PTGER2 7/4885PTGDR 20/4885
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885PTGDR 11/4885
US-20200188367-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20050065188-A1 Aryl or heteroaryl amide compounds HRH2, PTGER1, LTB4R2 PTGER4 13/4885PTGER2 11/4885PTGDR 16/4885
US-10973834-B2 EP4 inhibitors and use thereof PTGER4, EPB41, PTGER1 PTGER4 1/4885PTGER2 5/4885PTGDR 68/4885
US-20150111920-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-10611761-B2 Selective EP4 receptor antagonistic substance for treatment of cancer PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885PTGDR 7/4885
US-20240066040-A1 EP4 INHIBITORS AND USE THEREOF PTGER4, EPB41, PTGER1 PTGER4 1/4885PTGER2 5/4885PTGDR 68/4885
US-20090036495-A1 Combinations Comprising Alpha-2-Delta Ligands and Ep4 Receptor Antagonists PTGER4, PTGER2, OPRL1 PTGER4 1/4885PTGER2 2/4885PTGDR 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.