Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679607 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL413228 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL18938465 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL18934846 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL13060381 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL24618011 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL1678569 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL18935496 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| SCHEMBL21212072 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6EPHX1CES2CES1 | |
| Hydrochloric Acid SCHEMBL7274485 | 0.97 | HDAC8 (0.58) | HDAC8HDAC6EPHX1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009898-A1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |