Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levonorgestrel. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 8/20 | 1.00 |
| ▸ | AR | P10275 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | ESR1 | P03372 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | SHBG | P04278 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levonorgestrel SCHEMBL3916570 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL14360765 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL27597 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Norgestrel SCHEMBL37118 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Norgestrel SCHEMBL4319113 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL825664 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL22364344 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL21741985 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL20927506 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 | |
| Levonorgestrel SCHEMBL11697371 | 1.00 | PGR (1.00) | PGRARLMNACYP3A4SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200140290-A1 | Remediation of physiologically active compounds from waste water | SECURE NATURAL RESOURCES LLC (US) | 2020-05-07 | — | — | US | claimed |
| CN-105873572-A | Orally disintegrating porous film comprising pharmacological active ingredient and method for preparing same | 首尔制药株式会社 | 2016-08-17 | — | — | CN | claimed |
| CN-103068744-A | Remediation of Physiologically Active Compounds from Wastewater | MOLYCORP MINERALS LLC | 2013-04-24 | — | — | CN | claimed |
| EP-2580165-A1 | REMEDIATION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS FROM WASTE WATER | Molycorp Minerals, LLC (US) | 2013-04-17 | — | — | EP | claimed |
| CN-101346134-B | Use of film-forming hair-care polymers from the group of polyurethanes and pharmaceutical preparations and plasters containing the polymers | EPINAMICS GMBH | 2013-03-27 | — | — | CN | claimed |
| CN-101346134-A | Use of film-forming hair-care polymers from the group of polyurethanes and pharmaceutical preparations and plasters containing said polymers | EPINAMICS GMBH (DE) | 2009-01-14 | — | — | CN | claimed |
| CN-100393360-C | Compositon comprising a combination of an aromatase inhibitor, a progestin and an oestrogen and its use for the treatment of endometriosis | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | CN | claimed |
| CN-1747736-A | Compositon comprising a combination of an aromatase inhibitor, a progestin and an oestrogen and its use for the treatment of endometriosis | ASTRAZENECA AB (SE) | 2006-03-15 | — | — | CN | claimed |
| CN-1239153-C | Transdermal therapeutic system based on polyacrylate-contact-bonding adhesives without functional groups | LOHMANN THERAPIE SYST LTS (DE) | 2006-02-01 | — | — | CN | claimed |
| CN-1545408-A | Transdermal therapeutic system based on polyacrylate adhesive patches without functional groups | LTS��������ϵͳ�ɷݹ�˾ | 2004-11-10 | — | — | CN | claimed |
| CN-1024753-C | Contraceptive implant | AKZO NV (NL) | 1994-06-01 | — | — | CN | claimed |
| EP-0397823-A4 | CONTRACEPTION SYSTEM AND METHOD | — | 1991-04-03 | — | — | EP | claimed |
| EP-0397823-A1 | CONTRACEPTION SYSTEM AND METHOD | BIO-TECHNOLOGY GENERAL CORP. (US) | 1990-11-22 | — | — | EP | claimed |
| WO-1990004330-A1 | CONTRACEPTION SYSTEM AND METHOD | PASQUALE SAMUEL A (US) | 1990-05-03 | — | — | WO | claimed |
| US-4921843-A | Contraception system and method | GYNEX PHARMACEUTICALS, INC. A NV CORPORATION | 1990-05-01 | — | — | US | claimed |
| CN-1031323-A | CONTRACEPTIVE IMPLANT | AKZO NV (NL) | 1989-03-01 | — | — | CN | claimed |
| US-4628051-A | LOW DOSAGE OF ESTROGEN AND PROGESTOGEN | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-09 | — | — | US | claimed |
| US-4616006-A | ADMINISTERING COMBINATIONS OF ESTROGEN AND PROGESTOGEN | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-10-07 | — | — | US | claimed |
| US-4544554-A | STEROID COMBINATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1985-10-01 | — | — | US | claimed |
| US-4145416-A | ESTRADIOL AND ESTRIOL DERIVATIVES | SCHERING, A.G. (DE) | 1979-03-20 | — | — | US | claimed |