Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 11/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11503532 | 0.84 | CYP3A4 (0.52) | FGFR1KDRCYP3A4CASP1RECQL | |
| SCHEMBL12412921 | 0.84 | MEN1 (0.51) | FGFR1KDRGRM5CYP3A4CASP1 | |
| SCHEMBL7875534 | 0.82 | CYP3A4 (0.50) | FGFR1KDRCYP3A4CASP1RECQL | |
| SCHEMBL7877899 | 0.81 | CYP3A4 (0.48) | FGFR1KDRCYP3A4CASP1RECQL | |
| SCHEMBL1467374 | 0.79 | FGFR1 (0.49) | FGFR1KDRCYP3A4CASP1RECQL | |
| SCHEMBL12830501 | 0.78 | GRM5 (0.62) | GRM5 | |
| SCHEMBL29755998 | 0.76 | KDR (0.44) | FGFR1KDRCYP3A4CASP1RECQL | |
| SCHEMBL1982712 | 0.75 | GRM5 (0.57) | GRM5CYP3A4MEN1 | |
| SCHEMBL12412935 | 0.74 | GRM5 (0.46) | GRM5DHFR | |
| SCHEMBL1982029 | 0.73 | GRM5 (0.50) | GRM5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035209-A1 | SUBSTITUTED BENZAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSTIY (US) | 2011-03-24 | — | — | WO | disclosed |