SCHEMBL7877899

SCHEMBL7877899

CN(c1ccc(N(C)c2cccc(N)c2)cc1)c1cccc(N)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.48
CASP1 P29466 2/20 0.48
RECQL P46063 1/20 0.48
KDR P35968 2/20 0.47
FGFR1 P11362 1/20 0.47
ALDH1A1 P00352 6/20 0.41
TDP1 Q9NUW8 3/20 0.41
TP53 P04637 2/20 0.41
ALOX15 P16050 2/20 0.41
MAPK1 P28482 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
EGFR P00533 1/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
DHFR P00374 1/20 0.39
MTNR1A P48039 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11503532 0.95 CYP3A4 (0.52) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL29755998 0.94 KDR (0.44) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL1467374 0.93 FGFR1 (0.49) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL7875534 0.93 CYP3A4 (0.50) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL7875523 0.86 ALDH1A1 (0.52) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL23142746 0.83 KDR (0.38) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL374790 0.81 ALDH1A1 (0.54) CYP3A4CASP1RECQLALDH1A1TDP1
SCHEMBL29647628 0.81 ALDH1A1 (0.54) CYP3A4CASP1RECQLALDH1A1TDP1
SCHEMBL6918689 0.81 FGFR1 (0.41) CYP3A4CASP1RECQLKDRFGFR1
SCHEMBL22339998 0.80 KDR (0.41) CYP3A4CASP1RECQLKDRFGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6320019-B1 REACTING A TETRACARBOXYLIC DIANHYDRIDE, AN AROMATIC DIAMINE, A DIAMINE WITH A SILOXANE STRUCTURE, AND AN AROMATIC TRI- OR TETRAAMINE WITH TWO PHENYL GROUPS SAEHAN INDUSTRIES INCORPORATION (KR) 2001-11-20 US disclosed