Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919184 | 0.82 | ALDH1A1 (0.48) | ALDH1A1ROCK2HDAC8HDAC6MAPK1 | |
| SCHEMBL6919150 | 0.80 | ALDH1A1 (0.48) | ALDH1A1ROCK2HDAC8HDAC6ROCK1 | |
| SCHEMBL6919879 | 0.78 | TLR7 (0.53) | ALDH1A1ROCK2HDAC8HDAC6ROCK1 | |
| SCHEMBL2440129 | 0.78 | BAZ2B (0.47) | ALDH1A1ROCK2RAB9AHDAC8HDAC6 | |
| SCHEMBL6919822 | 0.78 | ALDH1A1 (0.46) | ALDH1A1ROCK2HDAC8HDAC6ROCK1 | |
| SCHEMBL12279819 | 0.77 | ALDH1A1 (0.57) | ALDH1A1ROCK2NPC1HDAC8HDAC6 | |
| SCHEMBL2438985 | 0.77 | ALDH1A1 (0.48) | ALDH1A1ROCK2HDAC8HDAC6MAPK1 | |
| SCHEMBL6917439 | 0.76 | ALDH1A1 (0.47) | ALDH1A1ROCK2HDAC8HDAC6MAPK1 | |
| SCHEMBL2407405 | 0.76 | HTT (0.55) | ALDH1A1ROCK2RAB9AMAPK1ROCK1 | |
| SCHEMBL2411612 | 0.76 | ALDH1A1 (0.47) | ALDH1A1ROCK2NPC1RAB9AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |