Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ipratropium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 3/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ipratropium SCHEMBL4231044 | 0.84 | CHRM2 (0.63) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL2166848 | 0.84 | CHRM2 (0.63) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL28250222 | 0.84 | CHRM2 (0.65) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL28223580 | 0.83 | CHRM2 (0.64) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL2169666 | 0.83 | CHRM2 (0.64) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL28250221 | 0.83 | CHRM2 (0.63) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL2167530 | 0.82 | CHRM2 (0.60) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL27974717 | 0.82 | CHRM2 (0.60) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL29400593 | 0.82 | CHRM2 (0.60) | CHRM2CHRM5CHRM4CHRM1CHRM3 | |
| Ipratropium SCHEMBL117888 | 0.81 | CHRM2 (0.60) | CHRM2CHRM5CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340716-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA | UNIVERSITY OF INDIANA RESEARCH & TECHNOLOGY CORPORATION | 2017-11-30 | — | — | US | disclosed |
| EP-2421552-B1 | COLLAGEN V FOR USE IN THE TREATMENT OF ASTHMA | UNIV INDIANA RES & TECH CORP (US) | 2016-12-14 | — | — | EP | disclosed |
| US-8568730-B2 | Compositions for use in the treatment of chronic obstructive pulmonary diseases and asthma | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130195903-A1 | COMPOSITIONS FOR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ASTHMA | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2013-08-01 | — | — | US | disclosed |
| US-20120052081-A1 | COMPOSITIONS FOR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ASTHMA | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2012-03-01 | — | — | US | disclosed |
| EP-2421552-A1 | Compositions for use in the treatment of chronic obstructive pulmonary diseases and asthma | Indiana University Research and Technology Corporation (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124058-A1 | COMPOSITIONS FOR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ASTHMA | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2010-10-28 | — | — | WO | disclosed |