Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 15/20 | 0.76 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285388 | 0.92 | PTGER4 (0.86) | PTGER4PTGER2 | |
| SCHEMBL19714369 | 0.92 | PTGER4 (0.86) | PTGER4PTGER2 | |
| SCHEMBL692240 | 0.90 | PTGER4 (0.72) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL691905 | 0.89 | PTGER4 (0.77) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL5367764 | 0.86 | PTGER4 (0.68) | PTGER4PTGER2SCN9A | |
| SCHEMBL691840 | 0.86 | PTGER4 (0.75) | PTGER4PTGER2MAPK8ALDH1A1HPGD | |
| SCHEMBL692029 | 0.85 | PTGER4 (0.69) | PTGER4PTGER2MAPK8ROCK2ROCK1 | |
| SCHEMBL19713760 | 0.85 | PTGER4 (0.82) | PTGER4PTGER2 | |
| SCHEMBL2347975 | 0.85 | PTGER4 (0.82) | PTGER4PTGER2 | |
| SCHEMBL30114906 | 0.85 | PTGER4 (0.82) | PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422779-A1 | SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2012-02-29 | — | — | EP | claimed |
| EP-3431085-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | AskAt Inc. (JP) | 2019-01-23 | — | — | EP | disclosed |
| EP-2965756-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2422779-A1 | SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | RaQualia Pharma Inc (JP) | 2012-02-29 | — | — | EP | disclosed |