Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 14/20 | 0.76 |
| ▸ | ITGB2 | P05107 | 12/20 | 0.76 |
| ▸ | ICAM1 | P05362 | 12/20 | 0.76 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641657 | 1.00 | ITGAL (0.76) | ITGALITGB2ICAM1RAB9ANPC1 | |
| SCHEMBL6493588 | 0.90 | ITGAL (0.73) | ITGALITGB2ICAM1RAB9ANPC1 | |
| SCHEMBL6493194 | 0.90 | ITGAL (0.73) | ITGALITGB2ICAM1RAB9ANPC1 | |
| SCHEMBL6317727 | 0.90 | ITGAL (0.73) | ITGALITGB2ICAM1RAB9ANPC1 | |
| SCHEMBL6569818 | 0.90 | ITGAL (0.73) | ITGALITGB2ICAM1RAB9ANPC1 | |
| SCHEMBL6310695 | 0.86 | ITGAL (0.68) | ITGALITGB2ICAM1L3MBTL1 | |
| SCHEMBL6568431 | 0.86 | ITGAL (0.68) | ITGALITGB2ICAM1L3MBTL1 | |
| SCHEMBL7645229 | 0.86 | ITGAL (0.62) | ITGALITGB2ICAM1 | |
| SCHEMBL6567852 | 0.85 | ITGAL (0.61) | ITGALITGB2ICAM1 | |
| SCHEMBL6568435 | 0.84 | ITGAL (0.57) | ITGALITGB2ICAM1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059880-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165505-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2004-09-08 | — | — | EP | disclosed |