Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.52 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516737 | 0.91 | BACE1 (0.55) | BACE1BACE2CYP2D6CTSD | |
| SCHEMBL11918196 | 0.87 | BACE1 (0.59) | BACE1BACE2CYP2D6CTSD | |
| SCHEMBL990426 | 0.87 | BACE1 (0.63) | BACE1BACE2CYP2D6 | |
| SCHEMBL990541 | 0.85 | BACE1 (0.51) | BACE1BACE2CYP2D6 | |
| SCHEMBL6921600 | 0.83 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL6920129 | 0.81 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL15835731 | 0.81 | BACE1 (0.60) | BACE1BACE2CYP2D6CTSD | |
| SCHEMBL990605 | 0.81 | BACE1 (0.61) | BACE1BACE2CYP2D6 | |
| SCHEMBL6919726 | 0.80 | BACE1 (0.37) | BACE1BACE2CTSD | |
| SCHEMBL990549 | 0.80 | BACE1 (0.57) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139594-B2 | Fused aminodihydropyrimidone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| WO-2011009897-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |