Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 4/20 | 0.66 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 10/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | HTT | P42858 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594659 | 1.00 | CXCR1 (0.66) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL5595038 | 0.88 | MEN1 (0.74) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL5595104 | 0.86 | CXCR1 (0.80) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL6823411 | 0.85 | KMT2A (0.53) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL5595106 | 0.85 | KMT2A (0.69) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL6823083 | 0.85 | MAPT (0.60) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL5595504 | 0.84 | CXCR1 (0.66) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7489293 | 0.83 | MEN1 (0.67) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL18013179 | 0.82 | TRPV1 (0.76) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL6824010 | 0.81 | KMT2A (0.50) | CXCR1CXCR2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |