Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.65 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595038 | 0.94 | MEN1 (0.74) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL5595118 | 0.93 | CXCR2 (0.74) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL5595106 | 0.83 | KMT2A (0.69) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL6920109 | 0.83 | CXCR1 (0.66) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL5594659 | 0.83 | CXCR1 (0.66) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL7489294 | 0.82 | KMT2A (0.51) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL5595104 | 0.82 | CXCR1 (0.80) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL6824010 | 0.81 | KMT2A (0.50) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL7494939 | 0.80 | CXCR2 (0.63) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL3706835 | 0.80 | KMT2A (0.74) | MEN1KMT2AMAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |