Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690575 | 0.93 | PTK2 (0.58) | PTK2MAPK1MAPK3RPS6KA1LMNA | |
| SCHEMBL691543 | 0.92 | PTK2 (0.60) | PTK2MAPK1MAPK3RPS6KA1LMNA | |
| SCHEMBL692967 | 0.89 | PTK2 (0.73) | PTK2MAPK1MAPK3MAPK9MAPK10 | |
| SCHEMBL691390 | 0.89 | PTK2 (0.46) | PTK2MAPK1MAPK3RPS6KA1LMNA | |
| SCHEMBL22174998 | 0.89 | PTK2 (0.62) | PTK2MAPK1MAPK3RPS6KA1MAPK14 | |
| SCHEMBL1292976 | 0.87 | PTK2 (0.60) | PTK2MAPK1MAPK3RPS6KA1MAPK14 | |
| SCHEMBL692011 | 0.85 | PTK2 (0.80) | PTK2MAPK1MAPK3RPS6KA1MAPK14 | |
| SCHEMBL1292996 | 0.84 | MAPK1 (0.52) | PTK2MAPK1MAPK3RPS6KA1MAPK9 | |
| SCHEMBL691573 | 0.84 | MAPK1 (0.50) | PTK2MAPK1MAPK3RPS6KA1LMNA | |
| SCHEMBL691964 | 0.82 | MAPK1 (0.63) | PTK2MAPK1MAPK3RPS6KA1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |