Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691573 | 0.93 | MAPK1 (0.50) | PTK2MAPK1MAPK3KDM4CFTO | |
| SCHEMBL691084 | 0.91 | PTK2 (0.47) | PTK2MAPK1MAPK3KDM4CFABP3 | |
| SCHEMBL692012 | 0.89 | PTK2 (0.58) | PTK2MAPK1MAPK3KDM4CRPS6KA1 | |
| SCHEMBL691296 | 0.88 | PTK2 (0.56) | PTK2MAPK1MAPK3KDM4CFTO | |
| SCHEMBL689985 | 0.85 | PTK2 (0.45) | PTK2MAPK1MAPK3KDM4CKDM4E | |
| SCHEMBL691211 | 0.84 | PTK2 (0.44) | PTK2MAPK1MAPK3KDM4CFTO | |
| SCHEMBL1292996 | 0.84 | MAPK1 (0.52) | PTK2MAPK1MAPK3RPS6KA1 | |
| SCHEMBL690575 | 0.84 | PTK2 (0.58) | PTK2MAPK1MAPK3KDM4CRPS6KA1 | |
| SCHEMBL691389 | 0.84 | PTK2 (0.64) | PTK2MAPK1MAPK3FABP3FABP4 | |
| SCHEMBL691451 | 0.83 | MAPK1 (0.38) | PTK2MAPK1MAPK3RPS6KA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |