Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920501 | 0.88 | BACE1 (0.42) | BACE1BACE2 | |
| SCHEMBL8516712 | 0.88 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL8516710 | 0.88 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL6921552 | 0.87 | DRD2 (0.40) | BACE1BACE2 | |
| SCHEMBL6920129 | 0.84 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL6920107 | 0.83 | BACE1 (0.38) | BACE1BACE2 | |
| SCHEMBL11918196 | 0.81 | BACE1 (0.59) | BACE1BACE2 | |
| SCHEMBL287319 | 0.77 | BACE2 (0.50) | BACE1BACE2 | |
| SCHEMBL287318 | 0.77 | BACE2 (0.50) | BACE1BACE2 | |
| SCHEMBL8020348 | 0.76 | BACE1 (0.50) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139594-B2 | Fused aminodihydropyrimidone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-20120202828-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-09 | — | — | US | disclosed |
| WO-2011009897-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202828-A1 | FUSED AMINODIHYDROPYRIMIDONE DERIVATIVES | BACE1, APP, BACE2 | BACE1 1/4885BACE2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.