Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919998 | 0.95 | MEN1 (0.49) | MEN1KMT2AESR1ESR2PLA2G2A | |
| SCHEMBL7505287 | 0.94 | ESR1 (0.44) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6924574 | 0.93 | ESR1 (0.41) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6924126 | 0.93 | ESR1 (0.43) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6921487 | 0.85 | ESR1 (0.43) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6927305 | 0.84 | ESR1 (0.42) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6926705 | 0.84 | TP53 (0.43) | MEN1KMT2AESR1ESR2BIRC5 | |
| SCHEMBL6927241 | 0.84 | DRD2 (0.51) | MEN1KMT2AESR1ESR2PLA2G2A | |
| SCHEMBL6927808 | 0.84 | DRD2 (0.46) | MEN1KMT2AESR1ESR2PLA2G2A | |
| SCHEMBL6925514 | 0.84 | MAPK1 (0.48) | MEN1KMT2AESR1ESR2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |