Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 13/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.39 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718031 | 0.88 | ITGAV (0.51) | ITGAVITGB3CXCR4ITGB6ITGB5 | |
| SCHEMBL7797597 | 0.81 | ITGAV (0.51) | ITGAVITGB3CXCR4ITGB6ITGB5 | |
| SCHEMBL12895016 | 0.81 | ITGAV (0.47) | ITGAVITGB3CXCR4CACNA2D1ITGB6 | |
| SCHEMBL4717885 | 0.80 | CXCR4 (0.48) | ITGAVITGB3CXCR4CACNA2D1ITGB6 | |
| SCHEMBL13833866 | 0.78 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL30336058 | 0.78 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL3138678 | 0.77 | ITGAV (0.54) | ITGAVITGB3CXCR4ITGB6ITGB5 | |
| SCHEMBL12807006 | 0.77 | ITGAV (0.58) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL4389527 | 0.77 | ITGAV (0.46) | ITGAVITGB3CXCR4ITGB6ITGB5 | |
| SCHEMBL22893606 | 0.76 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB5ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514964-B1 | Treating diseases, conditions or disorders mediated by integrin receptors, such as vitronectin and fibronectin receptors | AMGEN INC. | 2003-02-04 | — | — | US | disclosed |