Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 9/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 9/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 8/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 2/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880805 | 0.86 | RXRA (0.52) | BACE1PTGER4PTGER2PTGER3PTGER1 | |
| SCHEMBL6921631 | 0.80 | RARG (0.33) | RXRACYP26A1RARACYP26B1 | |
| SCHEMBL6880784 | 0.74 | RXRA (0.52) | PTGER4PTGER2PTGER3PTGER1RXRA | |
| SCHEMBL6879445 | 0.74 | RXRA (0.56) | PTGER4PTGER2PTGER3PTGER1RXRA | |
| SCHEMBL6879963 | 0.72 | RXRA (0.49) | PTGER4PTGER2PTGER3PTGER1RXRA | |
| SCHEMBL6472627 | 0.72 | CYP26A1 (0.42) | RXRASMN1; SMN2CYP26A1CYP3A4RARA | |
| SCHEMBL6472625 | 0.72 | CYP26A1 (0.42) | RXRASMN1; SMN2CYP26A1CYP3A4RARA | |
| SCHEMBL4653617 | 0.70 | KDM4E (0.51) | BACE1PTGER4PTGER2PTGER3PTGER1 | |
| SCHEMBL4653615 | 0.70 | KDM4E (0.51) | BACE1PTGER4PTGER2PTGER3PTGER1 | |
| SCHEMBL6874750 | 0.69 | RXRA (0.47) | BACE1RXRASMN1; SMN2CYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515021-B1 | Bicyclic aromatic compounds | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2003-02-04 | — | — | US | claimed |
| US-6147255-A | TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL COMPLAINTS ASSOCIATED WITH KERATINIZATION DISORDER WHICH HAS EFFECT ON DIFFERENTIATION AND ON PROLIFERATION | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-11-14 | — | — | US | claimed |