SCHEMBL692172

SCHEMBL692172

C[C@H](NC(=O)c1cc(Cl)ccc1COc1cccc(Cl)c1)c1ccc(C(=O)O)cc1

nearest known ligand 0.70

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 18/20 0.70
PTGER2 P43116 5/20 0.63
RXRA P19793 1/20 0.54
RXRB P28702 1/20 0.54
RXRG P48443 1/20 0.54
PTGDR Q13258 1/20 0.53
NR4A1 P22736 1/20 0.51
NR4A2 P43354 1/20 0.51
NR4A3 Q92570 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5188816 1.00 PTGER4 (0.70) PTGER4PTGER2RXRARXRBRXRG
SCHEMBL691395 0.93 PTGER4 (0.73) PTGER4PTGER2PTGDR
SCHEMBL19714256 0.93 PTGER4 (0.73) PTGER4PTGER2PTGDR
SCHEMBL3977095 0.92 PTGER4 (0.59) PTGER4PTGER2PTGDRNR4A1NR4A2
SCHEMBL3980141 0.91 PTGER4 (0.58) PTGER4PTGER2
SCHEMBL692553 0.91 PTGER4 (0.64) PTGER4PTGER2RXRARXRBNR4A2
SCHEMBL22076482 0.88 PTGER4 (0.61) PTGER4PTGER2NR4A2
SCHEMBL692175 0.88 PTGER4 (0.61) PTGER4PTGER2NR4A2
SCHEMBL15463555 0.88 PTGER4 (0.58) PTGER4PTGER2NR4A2
SCHEMBL691363 0.88 PTGER4 (0.63) PTGER4PTGER2PTGDRNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2017-09-07 US claimed
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2016-11-03 US claimed
EP-2976105-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE AskAt Inc. (JP) 2016-01-27 EP claimed
WO-2014148053-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2014-09-25 WO claimed
EP-1756042-B1 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS RAQUALIA PHARMA INC (JP) 2014-02-12 EP claimed
EP-2538978-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RaQualia Pharma Inc (JP) 2013-01-02 EP claimed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US claimed
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RAQUALIA PHARMA INC. (JP) 2012-04-12 US claimed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP claimed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO claimed
US-20090163558-A1 Substituted Methyl Aryl or Heteroaryl Amide Compounds RAQUALIA PHARMA INC. (JP) 2009-06-25 US claimed
US-7534914-B2 Substituted methyl aryl or heteroaryl amide compounds REQUALIA PHARMA INC. (JP) 2009-05-19 US claimed
EP-1756042-A1 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS Pfizer, Inc. (US) 2007-02-28 EP claimed
US-20050267170-A1 Substituted methyl aryl or heteroaryl amide compounds PFIZER INC 2005-12-01 US claimed
WO-2005105732-A1 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS PFIZER JAPAN INC. (JP) 2005-11-10 WO claimed
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2023-12-12 US disclosed
EP-2976105-B1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC (JP) 2023-01-04 EP disclosed
WO-2005105732-A1 SUBSTITUTED METHYL ARYL OR HETEROARYL AMIDE COMPOUNDS PFIZER JAPAN INC. (JP) 2005-11-10 WO disclosed
WO-2005102389-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-03 WO disclosed
WO-2005102389-A2 COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2005-11-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES PTGER4, PTGER3, IL23R PTGER4 1/4885PTGER2 6/4885RXRA 1374/4885
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885RXRA 1093/4885
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885RXRA 1020/4885
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885PTGER2 3/4885RXRA 923/4885
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER2 4/4885RXRA 648/4885
US-20090163558-A1 Substituted Methyl Aryl or Heteroaryl Amide Compounds PTGER1, PTGER2, PTGER3 PTGER4 14/4885PTGER2 2/4885RXRA 730/4885
US-20050267170-A1 Substituted methyl aryl or heteroaryl amide compounds PTGER1, PTGER2, PTGER3 PTGER4 14/4885PTGER2 2/4885RXRA 730/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.