Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130087 | 0.91 | TLR4 (0.44) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL542220 | 0.87 | MEN1 (0.47) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13250462 | 0.87 | MAPT (0.43) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3621568 | 0.85 | GAA (0.43) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL21358281 | 0.84 | MAPT (0.47) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3612755 | 0.84 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL652243 | 0.82 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL19073726 | 0.82 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL12134814 | 0.81 | ALDH1A1 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL14703832 | 0.81 | ALDH1A1 (0.45) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021051034-A1 | RAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2021-03-18 | — | — | WO | disclosed |
| EP-3710439-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-2421867-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | Auspex Pharmaceuticals, Llc (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2010123919-A2 | PIPERIDINE INHIBITORS OF JANUS KINASE 3 | AUSPEX PHARMACEUTICALS, LLC (US) | 2010-10-28 | — | — | WO | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |