SCHEMBL692223

SCHEMBL692223

O=C(O)C1=C(c2nccs2)C(=O)N=N1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.38
ECE1 P42892 1/20 0.38
ALDH1A1 P00352 1/20 0.34
GRIK1 P39086 1/20 0.34
GRIA1 P42261 1/20 0.34
GRIA2 P42262 1/20 0.34
GRIA3 P42263 1/20 0.34
GRIA4 P48058 1/20 0.34
GRIK2 Q13002 1/20 0.34
GRIK3 Q13003 1/20 0.34
GRIK4 Q16099 1/20 0.34
GRIK5 Q16478 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.32
AKR1C3 P42330 1/20 0.32
ADORA1 P30542 2/20 0.32
CYP1A2 P05177 1/20 0.32
ADORA2A P29274 1/20 0.32
HDAC2 Q92769 1/20 0.32
ABL1 P00519 1/20 0.31
BCR P11274 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28685835 0.74 PDPK1 (0.37) PDPK1ALDH1A1ADORA1CYP1A2ADORA2A
SCHEMBL692285 0.66 FGFR1 (0.43) ALDH1A1
SCHEMBL3222550 0.66 PDPK1 (0.44) PDPK1ECE1ALDH1A1AKR1C3CYP1A2
SCHEMBL102331 0.63 PDPK1 (0.59) PDPK1ALDH1A1ADORA1ADORA2ARAB9A
SCHEMBL25233984 0.63 HSP90AA1 (0.56) ECE1RAB9A
SCHEMBL2108348 0.63 PDPK1 (0.50) PDPK1ECE1ALDH1A1PTGDR2HDAC2
SCHEMBL29228755 0.63 PDPK1 (0.46) PDPK1ECE1ALDH1A1PTGDR2AKR1C3
SCHEMBL2177044 0.63 PDPK1 (0.60) PDPK1ALDH1A1PTGDR2HDAC2ABL1
SCHEMBL692332 0.63 TSHR (0.44) ALDH1A1NPC1RAB9A
SCHEMBL6558546 0.62 SPHK2 (0.46) PDPK1ECE1ALDH1A1CYP1A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421501-A2 KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF The Procter & Gamble Company (US) 2012-02-29 EP claimed
WO-2010123863-A2 KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF THE PROCTER & GAMBLE COMPANY (US) 2010-10-28 WO claimed
EP-2421501-A2 KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF The Procter & Gamble Company (US) 2012-02-29 EP disclosed
WO-2010123863-A2 KERATIN DYEING COMPOSITIONS COMPRISING A RADICAL SCAVENGER AND USE THEREOF THE PROCTER & GAMBLE COMPANY (US) 2010-10-28 WO disclosed