Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 1.00 |
| ▸ | ABL1 | P00519 | 3/20 | 0.89 |
| ▸ | TP53 | P04637 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10034089 | 0.94 | SRC (1.00) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL3859729 | 0.76 | ABL1 (0.62) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL3859724 | 0.76 | ABL1 (0.62) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL12935526 | 0.71 | KDM4E (1.00) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL6922303 | 0.70 | TP53 (0.60) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL13057346 | 0.68 | TP53 (0.52) | SRCABL1TP53KDM4ENPC1 | |
| SCHEMBL4772183 | 0.67 | ABL1 (0.51) | SRCABL1KDM4EALDH1A1HPGD | |
| SCHEMBL4772189 | 0.67 | ABL1 (0.51) | SRCABL1KDM4EALDH1A1HPGD | |
| SCHEMBL2236808 | 0.65 | MAPT (0.49) | SRCABL1KDM4ELMNAMAPT | |
| SCHEMBL2236815 | 0.65 | MAPT (0.49) | SRCABL1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004106339-A2 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-d] PYRIMIDINE AND PYRROLO [2,3-d] PYRIMIDINE AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2004-12-09 | — | — | WO | disclosed |