Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.51 |
| ▸ | SRC | P12931 | 7/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772183 | 1.00 | ABL1 (0.51) | ABL1SRCFYNRETSGK1 | |
| SCHEMBL3859724 | 0.74 | ABL1 (0.62) | ABL1SRCFYNSGK1EGFR | |
| SCHEMBL3859729 | 0.74 | ABL1 (0.62) | ABL1SRCFYNSGK1EGFR | |
| SCHEMBL28938204 | 0.72 | RECQL (0.42) | ABL1SRCFYNSGK1KDM4E | |
| SCHEMBL30095774 | 0.69 | KDM4E (0.62) | EGFRKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL3761998 | 0.69 | KDM4E (0.62) | EGFRKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL6880333 | 0.69 | EGFR (0.38) | EGFRKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL10507649 | 0.68 | NPC1 (0.44) | ABL1SRCKDM4EMEN1ALDH1A1 | |
| SCHEMBL10511571 | 0.68 | NPC1 (0.44) | ABL1SRCKDM4EMEN1ALDH1A1 | |
| SCHEMBL6922298 | 0.67 | SRC (1.00) | ABL1SRCKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638966-B1 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO ¬3,4-d PYRIMIDINE AND USES THEREOF | UNIV SIENA (IT) | 2008-03-19 | — | — | EP | claimed |
| US-20070010510-A1 | 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2007-01-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010510-A1 | 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof | DPYD, TYMP, TYMS | ABL1 2080/4885SRC 2106/4885FYN 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.