Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 15/20 | 0.70 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958900 | 0.93 | PRKD1 (0.77) | PRKD1MLLT1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL957994 | 0.92 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ALDH1A1MAPT | |
| SCHEMBL6923596 | 0.83 | PRKD1 (0.68) | PRKD1MLLT1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL959487 | 0.83 | PRKD1 (0.76) | PRKD1PRKD3PRKD2 | |
| SCHEMBL959488 | 0.83 | PRKD1 (0.76) | PRKD1PRKD3PRKD2 | |
| SCHEMBL936598 | 0.82 | PRKD1 (1.00) | PRKD1PRKD3PRKD2 | |
| SCHEMBL936600 | 0.82 | PRKD1 (1.00) | PRKD1PRKD3PRKD2 | |
| SCHEMBL13702168 | 0.82 | PRKD1 (0.61) | PRKD1MAPK14PLOD2PLOD3PLOD1 | |
| SCHEMBL964036 | 0.82 | PRKD1 (0.66) | PRKD1MLLT1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL935776 | 0.79 | PRKD1 (0.59) | PRKD1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |