Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 12/20 | 0.66 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923596 | 0.90 | PRKD1 (0.68) | PRKD1PRKD3PRKD2NPC1RAB9A | |
| SCHEMBL957994 | 0.89 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ALDH1A1 | |
| SCHEMBL958900 | 0.86 | PRKD1 (0.77) | PRKD1PRKD3PRKD2ALDH1A1MLLT1 | |
| SCHEMBL6923075 | 0.84 | PRKD1 (0.63) | PRKD1PRKD3PRKD2SMN1; SMN2ALDH1A1 | |
| SCHEMBL6922372 | 0.82 | PRKD1 (0.70) | PRKD1PRKD3PRKD2ALDH1A1MLLT1 | |
| SCHEMBL937644 | 0.81 | NPC1 (0.67) | PRKD1PRKD3PRKD2NPC1RAB9A | |
| SCHEMBL6923851 | 0.81 | PRKD1 (0.63) | PRKD1PRKD3PRKD2NPC1RAB9A | |
| SCHEMBL959487 | 0.80 | PRKD1 (0.76) | PRKD1PRKD3PRKD2 | |
| SCHEMBL959488 | 0.80 | PRKD1 (0.76) | PRKD1PRKD3PRKD2 | |
| SCHEMBL966138 | 0.80 | PRKD1 (0.62) | PRKD1PRKD3PRKD2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |