Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536280 | 0.86 | ALDH1A1 (0.57) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL9831511 | 0.84 | ALDH1A1 (0.52) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL6922508 | 0.80 | PDE7A (0.55) | CYP1A2CYP2C9CYP2C19ERN1TDP1 | |
| SCHEMBL11824913 | 0.78 | KMT2A (0.54) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL3067225 | 0.77 | ERN1 (0.53) | CYP1A2MAPTALDH1A1HTTTP53 | |
| SCHEMBL9934029 | 0.76 | CYP1A2 (0.57) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL6925412 | 0.76 | PDE7A (0.52) | LMNAERN1TDP1IDO1 | |
| SCHEMBL8394925 | 0.75 | ERN1 (0.44) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL16306939 | 0.75 | ERN1 (0.57) | ALDH1A1LMNAERN1GAA | |
| SCHEMBL16458919 | 0.75 | ERN1 (0.47) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |