Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922859 | 0.87 | NPC1 (0.39) | PRMT5WDR77NPC1RAB9ATDP1 | |
| SCHEMBL6920968 | 0.84 | NPC1 (0.42) | NPC1RAB9ATDP1NSD2CYP3A4 | |
| SCHEMBL6922198 | 0.80 | ALDH1A1 (0.60) | NPC1RAB9ATDP1NSD2ALDH1A1 | |
| SCHEMBL6923865 | 0.80 | NPC1 (0.42) | PRMT5WDR77NPC1RAB9ATDP1 | |
| SCHEMBL12059057 | 0.80 | NPC1 (0.42) | PRMT5WDR77NPC1RAB9ATDP1 | |
| SCHEMBL6920766 | 0.80 | POLB (0.41) | NPC1RAB9ATDP1NSD2ALDH1A1 | |
| SCHEMBL12059328 | 0.79 | MEN1 (0.60) | NPC1RAB9ATDP1NSD2ALDH1A1 | |
| SCHEMBL12059061 | 0.79 | NPC1 (0.41) | NPC1RAB9ATDP1NSD2CYP3A4 | |
| SCHEMBL6924136 | 0.78 | MEN1 (0.62) | NPC1RAB9ATDP1NSD2ALDH1A1 | |
| SCHEMBL6922421 | 0.78 | NPC1 (0.48) | NPC1RAB9ATDP1NSD2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |