Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ACACB | O00763 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527596 | 1.00 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL6457656 | 1.00 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL19200906 | 0.92 | ACACB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL5521105 | 0.86 | POLB (0.73) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL516877 | 0.85 | ACACB (0.62) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL516876 | 0.85 | ACACB (0.62) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL10378902 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL10379638 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL10671340 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL517633 | 0.84 | RECQL (0.91) | POLBHPGDSMN1; SMN2GAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |