Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ACACB | O00763 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379638 | 1.00 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL10671340 | 1.00 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL5521105 | 0.86 | POLB (0.73) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL6457656 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL527596 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL6922906 | 0.85 | POLB (0.71) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL21444578 | 0.84 | RECQL (0.91) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL9927461 | 0.84 | RECQL (0.91) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL517633 | 0.84 | RECQL (0.91) | POLBHPGDSMN1; SMN2GAARECQL | |
| SCHEMBL9057935 | 0.83 | RECQL (0.94) | POLBHPGDSMN1; SMN2GAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215601-B1 | CYCLOALKYL-SUBSTITUTED 4-AMINOPHENYL DERIVATIVES AND PROCESSFOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1990-03-14 | — | — | EP | disclosed |
| US-4769483-A | Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation | FARMITALIA CARLO ERBA, S.P.A. (IT) | 1988-09-06 | — | — | US | disclosed |
| EP-0215601-A2 | Cycloalkyl-substituted 4-aminophenyl derivatives and processfor their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1987-03-25 | — | — | EP | disclosed |