SCHEMBL6922984

SCHEMBL6922984

COC(=O)c1cccc2c1CCNC2=O

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 10/20 0.58
PARP10 Q53GL7 4/20 0.58
PARP11 Q9NR21 4/20 0.58
ACHE P22303 1/20 0.46
PTPRC P08575 1/20 0.46
SLC6A4 P31645 2/20 0.44
SLC6A3 Q01959 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21496748 0.86 ROCK1 (0.50) PARP1PTPRC
SCHEMBL6923565 0.84 PARP1 (0.56) PARP1PARP10PARP11ACHE
SCHEMBL3872064 0.81 KDM4E (0.45) PARP1
SCHEMBL31752914 0.81 KDM4E (0.45) PARP1
SCHEMBL27883759 0.81 PARP1 (0.65) PARP1PARP10PARP11ACHE
SCHEMBL1959787 0.80 PARP1 (0.44) PARP1PARP10PARP11SLC6A4SLC6A3
SCHEMBL4998561 0.80 PARP1 (0.74) PARP1
SCHEMBL3002237 0.80 PARP1 (0.63) PARP1PARP10PARP11ACHE
SCHEMBL30853838 0.80 PARP1 (0.63) PARP1PARP10PARP11ACHE
SCHEMBL31305912 0.78 PTPRC (0.50) PTPRCSLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS INC (US) 2026-04-23 US disclosed
CN-113939288-B Modulators of MAS-related G protein receptor X4 and related products and methods 伊赛恩特制药公司 2025-04-25 CN disclosed
CN-115397412-B Modulators of MAS-related G protein receptor X4 and related products and methods 伊赛恩特制药公司 2025-03-25 CN disclosed
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2024-09-12 US disclosed
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-12 US disclosed
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-12 US disclosed
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-12-12 US disclosed
US-11787767-B2 Modulators of mas-related g-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-10-17 US disclosed
US-11787767-B2 Modulators of mas-related g-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-10-17 US disclosed
US-11787767-B2 Modulators of mas-related g-protein receptor X4 and related products and methods ESCIENT PHARMACEUTICALS, INC. (US) 2023-10-17 US disclosed
CN-113939288-A Modulators of MAS-related G protein receptor X4 and related products and methods 伊赛恩特制药公司 2022-01-14 CN disclosed
US-20210340106-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. 2021-11-04 US disclosed
US-20210340106-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. 2021-11-04 US disclosed
WO-2021211839-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2021-10-21 WO disclosed
WO-2021211839-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2021-10-21 WO disclosed
US-20210032213-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2021-02-04 US disclosed
US-20210032213-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS INCYTE CORPORATION 2021-02-04 US disclosed
WO-2020198537-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2020-10-01 WO disclosed
WO-2020198537-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2020-10-01 WO disclosed
WO-2011009484-A1 ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS NOVARTIS AG (CH) 2011-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11840521-B2 Modulators of Mas-related G-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4386/4885PARP10 2728/4885PARP11 2042/4885
US-11787767-B2 Modulators of mas-related g-protein receptor X4 and related products and methods MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4437/4885PARP10 3119/4885PARP11 2282/4885
US-20210032213-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4395/4885PARP10 2732/4885PARP11 2071/4885
US-20210340106-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4437/4885PARP10 3119/4885PARP11 2282/4885
US-20260108482-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4260/4885PARP10 3171/4885PARP11 2352/4885
US-20240300907-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS MRGPRX4, MRGPRX1, MRGPRX2 PARP1 4386/4885PARP10 2728/4885PARP11 2042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.