Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922950 | 0.82 | GRM4 (0.52) | GRM4 | |
| SCHEMBL17011306 | 0.80 | GRM4 (0.59) | GRM4 | |
| SCHEMBL6923982 | 0.79 | GRM4 (0.49) | GRM4 | |
| SCHEMBL19801454 | 0.75 | GRM4 (0.63) | GRM4 | |
| SCHEMBL28939044 | 0.75 | GRM4 (0.57) | GRM4 | |
| SCHEMBL6923917 | 0.69 | GRM4 (1.00) | GRM4 | |
| SCHEMBL19100876 | 0.69 | GRM4 (0.61) | GRM4 | |
| SCHEMBL6923497 | 0.69 | GRM4 (1.00) | GRM4 | |
| SCHEMBL2359725 | 0.68 | GRM4 (1.00) | GRM4 | |
| SCHEMBL14867348 | 0.68 | GRM4 (0.78) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100607-A1 | PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |