Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922880 | 0.80 | GRM2 (0.42) | GRM2NPC1RAB9ANSD2TDP1 | |
| SCHEMBL6922693 | 0.76 | GRM2 (0.41) | GRM2NPC1RAB9ANSD2TDP1 | |
| SCHEMBL14239848 | 0.75 | NPC1 (0.41) | GRM2NPC1RAB9ANSD2TDP1 | |
| SCHEMBL14239067 | 0.72 | METAP2 (0.40) | NPC1RAB9ANSD2TDP1 | |
| SCHEMBL12059030 | 0.70 | NPC1 (0.42) | NPC1RAB9ANSD2TDP1ALDH1A1 | |
| SCHEMBL14239843 | 0.69 | POLB (0.43) | NPC1RAB9ANSD2TDP1POLB | |
| SCHEMBL14239367 | 0.69 | NPC1 (0.40) | NPC1RAB9ANSD2TDP1ALDH1A1 | |
| SCHEMBL6923029 | 0.68 | IP6K1 (0.41) | NPC1RAB9ANSD2TDP1ALDH1A1 | |
| SCHEMBL2053729 | 0.68 | IP6K1 (0.41) | NPC1RAB9ANSD2TDP1ALDH1A1 | |
| SCHEMBL6921974 | 0.67 | POLB (0.45) | NPC1RAB9ANSD2TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |