Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924320 | 0.86 | SMG1 (0.39) | CDK1CDK2SMG1KMT2ADYRK3 | |
| SCHEMBL6924644 | 0.86 | SMG1 (0.39) | CDK1CDK2SMG1KMT2APTPN11 | |
| SCHEMBL6925038 | 0.86 | SMG1 (0.39) | CDK1CDK2SMG1KMT2APTPN11 | |
| SCHEMBL6923488 | 0.84 | KDM4E (0.39) | CDK1CDK2SMG1KMT2ADYRK3 | |
| SCHEMBL6921614 | 0.83 | CDK1 (0.43) | CDK1CDK2SMG1KMT2ADYRK3 | |
| SCHEMBL6923498 | 0.83 | CDK1 (0.39) | CDK1CDK2SMG1KMT2AKDM4E | |
| SCHEMBL6923470 | 0.83 | CDK1 (0.41) | CDK1CDK2SMG1KMT2ADYRK3 | |
| SCHEMBL6924886 | 0.82 | ITGB2 (0.43) | CDK1CDK2SMG1DYRK3CCNT1 | |
| SCHEMBL6927844 | 0.78 | HRH3 (0.43) | CDK1CDK2SMG1KMT2ADYRK3 | |
| SCHEMBL6928029 | 0.77 | SMG1 (0.43) | CDK1CDK2SMG1KMT2ADYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514966-B2 | Neuropeptide Y antagonists such as 2-chloro-5-(4-(3,4-dich loro-phenyl)-1H-imidazol-2-yl)-pyridine | PFIZER INC. | 2003-02-04 | — | — | US | disclosed |