Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923470 | 0.90 | CDK1 (0.41) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6921614 | 0.85 | CDK1 (0.43) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6923494 | 0.84 | CDK1 (0.38) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6924320 | 0.84 | SMG1 (0.39) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6924886 | 0.83 | ITGB2 (0.43) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6924959 | 0.82 | WNT1 (0.40) | DYRK1ACDK1CDK2SMG1PIK3C3 | |
| SCHEMBL6923498 | 0.81 | CDK1 (0.39) | KDM4EPKMCDK1CDK2SMG1 | |
| SCHEMBL6926669 | 0.81 | SMG1 (0.41) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6928029 | 0.81 | SMG1 (0.43) | KDM4EPKMDYRK3CCNT1CDK9 | |
| SCHEMBL6927962 | 0.81 | WNT1 (0.44) | KDM4EDYRK1ASMG1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514966-B2 | Neuropeptide Y antagonists such as 2-chloro-5-(4-(3,4-dich loro-phenyl)-1H-imidazol-2-yl)-pyridine | PFIZER INC. | 2003-02-04 | — | — | US | disclosed |