Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | MB | P02144 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839985 | 0.76 | SLC6A4 (0.44) | ALDH1A1TP53CYP3A4TSHRALOX15 | |
| SCHEMBL1836271 | 0.76 | SLC6A4 (0.44) | ALDH1A1TP53CYP3A4TSHRALOX15 | |
| SCHEMBL10576154 | 0.68 | TSHR (0.59) | NPC1ALDH1A1TP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL6924304 | 0.68 | NPC1 (0.44) | NPC1SMN1; SMN2RAB9A | |
| SCHEMBL12647919 | 0.68 | ALDH1A1 (0.44) | NPC1ALDH1A1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL861674 | 0.65 | SMN1; SMN2 (0.84) | NPC1ALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL12302270 | 0.63 | NPC1 (0.59) | NPC1ALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL12302267 | 0.63 | NPC1 (0.69) | NPC1ALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL13965224 | 0.62 | AKR1C1 (0.58) | NPC1ALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL4858551 | 0.62 | MAPT (0.55) | NPC1ALDH1A1SMN1; SMN2HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354441-B2 | Oxazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110112080-A1 | OXAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112080-A1 | OXAZOLINE DERIVATIVES | TAAR1, HCRTR1, NPY1R | NPC1 785/4885ALDH1A1 325/4885TP53 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.