Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | STAT1 | P42224 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 6/20 | 0.60 |
| ▸ | CASP1 | P29466 | 3/20 | 0.60 |
| ▸ | CASP7 | P55210 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.54 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14307628 | 0.94 | KDM4E (0.73) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7912467 | 0.92 | KDM4E (0.73) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL14302130 | 0.90 | NPC1 (0.57) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL5108571 | 0.85 | KDM4E (0.58) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL14307631 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6506553 | 0.82 | MAPT (0.86) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL23743853 | 0.81 | KDM4E (0.74) | KDM4EALDH1A1RAB9ALMNAKMT2A | |
| SCHEMBL7123957 | 0.81 | NPC1 (0.80) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL16847217 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7019582 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329654-B2 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-12 | — | — | US | disclosed |
| US-6518301-B1 | Better selectivity than estrogen for the estrogen receptor-beta over receptor-alpha; treatment of Alzheimer's disease, anxiety, depression, osteoporosis, cardiovascular disease, rheumatoid arthritis, or prostate cancer | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | disclosed |
| EP-1173164-A2 | ESTROGEN RECEPTOR-BETA LIGANDS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000062765-A2 | ESTROGEN RECEPTOR-β LIGANDS | ASTRAZENECA AB (SE) | 2000-10-26 | — | — | WO | disclosed |